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What does a positive antinuclear antibody mean?

Very often I have patients who come in to my office concerned that they have an autoimmune condition such as lupus because they were found to have a positive antinuclear antibody (ANA) on laboratory testing. As a rheumatologist, it’s my job to find out if that positive ANA has any clinical significance. As a patient, it is key to understand what exactly an ANA means. So let’s break it down.

Antibodies are proteins that are made in large amounts by the immune system. They are essential in recognizing and fighting infectious organisms in the body. Sometimes these antibodies make an error and mistakenly recognize normal proteins in our bodies as being foreign. Antinuclear antibodies are autoantibodies -- antibodies that target the normal proteins within the nucleus of a cell. This becomes clinically significant when ANAs signal the body to begin targeting itself, which can lead to autoimmune diseases, including lupus, Sjogren’s syndrome, and mixed connective tissue disease. Clinical features that can emerge include but are not limited to fever, chills, joint swelling, nasal/oral ulcers, hair loss, severe dry eyes/dry mouth, and kidney disease. By itself, a positive ANA does not in any way mean you have an autoimmune disease or need treatment. It simply means that there are autoantibodies present. Without clinical features or lab abnormalities such as leukopenia (low white blood cell count), thrombocytopenia (low platelet count) or protein in the urine, a positive ANA means exactly that. You simply have a positive lab test without any features of an autoimmune disease.

How do you test for antinuclear antibodies? It’s simply a blood test, but it should only be checked if you begin having any of the symptoms mentioned above. Only about 10-13% of persons with a positive ANA test are found to have lupus, and up to 15% of completely healthy people have a positive ANA test without an autoimmune disease. The production of these autoantibodies is strongly age-dependent and increases to 35% in healthy individuals over the age of 65. Causes of a false-positive ANA include infection, malignancy, and certain medications. Therefore, a positive ANA test does not equal a diagnosis of lupus or any autoimmune or connective tissue disease.

When I have a patient with a positive ANA, it means I will need to order more blood tests and take a detailed history of their symptoms as well perform a detailed physical exam. Remember, a positive ANA does not equal an autoimmune disease. But also remember that if it is determined that you do have an autoimmune disease, there are treatment options for it.

So if you have a positive ANA, don’t panic. The next step is to see a rheumatologist who will determine if additional testing is needed and who will make sure you will get the best care for your particular situation.

Resources:

https://www.rheumatology.org

Meet the Author

Sheetal Gavankar, M.D.

Specialty: Rheumatology
Areas of Interest: Rheumatoid Arthritis & Systemic Lupus Erythematosus

Dr. Gavankar specializes in internal medicine and medical genetics and practices at the Hoag Health Center in Huntington Beach. Board certified in both Internal Medicine and Rheumatology, Dr. Gavankar chose to specialize in Rheumatology as it allows her the opportunity to help patients of all ages as well as diagnose and treat a variety of interesting and complex conditions. View Bio [+]